The Niacin Protocol: How I Rewired My Body’s Energy Grid and Unlocked a New Level of Vitality

Introduction: The City in a Fog

For years, Alex had felt like a resident in a city slowly losing its power.

The mornings were a struggle, shrouded in a persistent mental fog that no amount of coffee could burn away.

The days were marked by a low-grade, humming fatigue—not exhaustion, but a constant, draining static that interfered with focus, creativity, and joy.

It was a pervasive sense of being disconnected, of living inside a complex machine without the operating manual.

This city, Alex’s own body, was experiencing systemic issues: the streetlights of energy flickered erratically, the communication grid of the nervous system was crackling with interference, and a sense of sluggishness suggested that even the fundamental infrastructure was becoming congested.

The wake-up call arrived not as a sudden crisis, but as a quiet, clinical document: the results of an annual physical.

The numbers on the lipid panel were a stark, objective confirmation of the internal malaise.

High LDL, low HDL, elevated triglycerides—it was the language of a system on the brink.

The doctor’s advice was standard and sensible: diet, exercise, and a potential future with statins.

But for Alex, it was a catalyst.

It was the moment the passive resident decided to become the city’s chief engineer.

The lab report was no longer a verdict, but the first page of a detailed schematic.

The journey began with a single, fundamental question: What does it take to go from being a passenger in your own biology to the chief engineer of your internal city, capable of understanding its systems, diagnosing its faults, and executing a plan to restore its vitality? The investigation led to an old, powerful, and profoundly misunderstood tool: a simple B vitamin with a complex story.

Part I: The Engineer’s Report – A System on the Brink

The initial phase of any great engineering project is assessment.

Armed with the lab report, Alex began a deep dive into the city’s blueprints, moving from the initial confusion of medical jargon to a state of focused curiosity.

The goal was to understand not just what was wrong, but why.

This investigation revealed two critical system failures: the city’s plumbing was becoming dangerously clogged, and its power grid was suffering from a critical resource shortage.

Decoding the Clogged Pipes

The first order of business was to understand the language of the lipid panel.

The common narrative of “good” versus “bad” cholesterol felt overly simplistic.

The reality, Alex discovered, was a dynamic hydraulic system.

The body’s circulatory system is an intricate network of pipes, and cholesterol and fats are the substances flowing through them.

In this analogy, low-density lipoprotein (LDL) cholesterol functions like a thick, sticky sludge.

At healthy levels, it’s a necessary component, but in excess, it clings to the inner walls of the city’s arteries, narrowing the passageways and restricting flow.¹

High-density lipoprotein (HDL) cholesterol, conversely, is the city’s dedicated maintenance crew.

Its job is to scrub the pipes, pulling the sticky LDL sludge away from the artery walls and transporting it back to the processing plant—the liver—for disposal.²

Triglycerides are another problem altogether; they are like excess fuel barrels carelessly left floating in the water supply, further congesting the system and impeding flow.¹

Alex’s lab report indicated too much sludge, not enough maintenance crew, and far too many barrels clogging the pipes.

This is where niacin entered the picture.

Historically, high-dose niacin has been a tool used by physicians since the 1950s to manage exactly this kind of problem, a condition known as dyslipidemia.⁵

Its primary function in this context is to rebalance the city’s hydraulic system.

Therapeutic doses of niacin have been shown to effectively raise the levels of the HDL maintenance crews while simultaneously lowering the amount of LDL sludge and triglyceride barrels in circulation.³

The clinical thresholds for concern are clear: an HDL level below 40 mg/dL in men or 50 mg/dL in women is considered a significant risk factor for cardiovascular disease, highlighting the critical need for a robust maintenance team.²

The City-Wide Power Shortage

The clogged pipes explained the long-term risk, but they didn’t fully account for the immediate, daily experience of fatigue and brain fog.

The second part of the engineer’s report focused on the city’s power grid.

This revealed a more fundamental problem that connected Alex’s subjective feelings to objective science.

A city runs on electricity; the human body runs on a molecule called adenosine triphosphate (ATP).

The analogy holds: the city’s power grid is responsible for converting raw fuel (like coal or natural gas) into the electricity that powers every home, office, and streetlamp.

In the body, this process is called cellular metabolism, and it converts the food we eat into ATP.

Niacin, also known as vitamin B3, is not the power itself.

Rather, it is the essential raw material—the copper—used to build the transformers and high-tension wires of the grid.

Specifically, the body converts niacin into two vital coenzymes: nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).⁷

These two molecules are indispensable; they are required for more than 400 different enzymatic reactions, acting as the primary agents of energy transfer in core processes like glycolysis (breaking down sugar), fatty acid metabolism, and cellular respiration.⁵

Without sufficient niacin, the city suffers a copper shortage, and the entire power grid becomes inefficient and crippled.

A severe, clinical deficiency of niacin leads to a condition called pellagra, a total system blackout characterized by dermatitis, diarrhea, and dementia—a catastrophic failure of the skin, digestive system, and nervous system.³

While pellagra is rare in the developed world thanks to food fortification, this understanding reveals a critical point.

The modern diet, often heavy in processed foods or niacin-poor staples like corn (in which the niacin is chemically bound and difficult for the body to absorb), may not induce overt pellagra, but it can easily lead to a state of

subclinical insufficiency.⁹

This isn’t a total blackout, but a chronic, city-wide “brownout.” The lights still turn on, but they flicker.

The communications network still functions, but it’s filled with static.

This reframes the issue from merely avoiding a rare disease to actively pursuing optimal function—a central goal for anyone seeking to become the chief engineer of their own health.

Part II: The Power Source – Deconstructing Niacin Formulations

Once the systemic issues were identified—clogged pipes and a failing power grid—the next engineering challenge was to determine the best way to supply the critical resource, niacin, to the city.

Alex’s research quickly revealed that the delivery method was just as important, if not more so, than the material itself.

The world of niacin supplements was a confusing landscape of different forms, each with its own unique properties, benefits, and risks.

The Three Currents – Solid Forms of Niacin

The most common forms of niacin come as pills, but they are not created equal.

Their differences lie in their pharmacokinetics—how they are absorbed, distributed, metabolized, and excreted by the body.

Each can be understood as a different type of electrical current being sent into the city’s grid.

• Immediate-Release (IR) Niacin: This is the equivalent of a lightning strike. It delivers a massive, instantaneous surge of power into the grid. The entire dose is absorbed rapidly, at a rate of about 500 mg per hour.¹⁰ This approach is effective and gets the job done quickly, but it comes with a significant risk of overloading the local circuits, causing sparks, alarms, and a system-wide alert. This overload is experienced by the user as the infamous “niacin flush”.¹⁰
• Sustained-Release (SR) Niacin: This is a trickle charge. Developed in the 1960s to avoid the intense surge of IR niacin, this formulation releases the vitamin very slowly, at a rate of about 50 mg per hour.¹⁰ While this avoids the initial overload and reduces the flushing effect, it creates a different problem. It places a continuous, low-grade strain on the city’s main processing plant—the liver—for many hours. This prolonged metabolic stress significantly increases the risk of hepatotoxicity, or liver damage.¹⁰ It is for this reason that many SR niacin products are sold as over-the-counter supplements and are not FDA-approved for treating dyslipidemia.¹⁰
• Extended-Release (ER) Niacin: This is an optimized power curve. Available by prescription (e.g., Niaspan), this formulation is engineered to be the best of both worlds. Its dissolution rate is intermediate, falling between the rapid surge of IR and the slow trickle of SR, at about 100 mg per hour.¹⁰ This allows the dose to rise smoothly to a therapeutic level, hold it for a clinically effective period, and then taper off. This design provides the liver with a “break,” balancing efficacy with a reduced risk of both the flushing associated with IR and the hepatotoxicity associated with SR niacin.¹⁰

The choice between these formulations involves a critical metabolic trade-off.

The liver metabolizes niacin via two main pathways.

The first is a high-affinity, low-capacity “amidation” pathway, whose byproducts have been associated with liver stress.

The second is a low-affinity, high-capacity “conjugative” pathway, whose main byproduct, nicotinuric acid (NUA), is associated with flushing.¹⁰

IR niacin’s rapid absorption completely saturates the low-capacity amidation pathway, shunting the vast majority of the dose down the conjugative pathway, leading to a massive production of NUA and intense flushing.

SR niacin’s slow release keeps the amidation pathway engaged for a prolonged period, leading to a higher cumulative production of potentially hepatotoxic metabolites.

ER niacin’s intermediate rate balances these two pathways, mitigating the worst effects of both extremes.¹⁰

Table 1: Niacin Formulations – A Comparative Analysis

Formulation	Absorption Speed (Analogy)	Primary Benefit	Primary Risk	Typical Use Case	Regulatory Status (for Cholesterol)
Immediate-Release (IR)	Very Fast (“Lightning Strike”)	Potent, rapid effect on lipids	Intense flushing, itching, warmth 10	Medically supervised lipid management	FDA-approved (e.g., Niacor) 10
Sustained-Release (SR)	Very Slow (“Trickle Charge”)	Reduced flushing compared to IR	High risk of liver damage (hepatotoxicity) 10	General vitamin supplement (not for lipids)	Not FDA-approved for dyslipidemia 10
Extended-Release (ER)	Intermediate (“Optimized Power Curve”)	Balanced efficacy with reduced side effects	Lower risk of both flushing and liver damage	Medically supervised lipid management	FDA-approved (e.g., Niaspan) 10
“Flush-Free” (Inositol Hexanicotinate)	Negligible Conversion (“Empty Fuel Truck”)	No flushing	Ineffective for cholesterol modification 11	General vitamin B3 supplement	Not effective; not for dyslipidemia

The “Flush-Free” Mirage

In the search for a solution without side effects, Alex, like many consumers, encountered products labeled “flush-free” or “no-flush” niacin.

The promise is tempting: all the benefits with none of the discomfort.

However, the engineering reality is stark.

“Flush-free” niacin is like ordering a tanker of high-octane fuel for the city’s power plants, but the truck that arrives is filled with inert water.

It causes no explosions (the flush), but it also generates no power (the cholesterol benefit).

These products contain a different compound called inositol hexanicotinate.¹¹

The body is supposed to slowly break this molecule down to release nicotinic acid, the active form of niacin.

However, clinical evidence shows that this conversion is extremely inefficient.

Very little, if any, free nicotinic acid ever reaches the bloodstream.¹¹

Consequently, it does not have the beneficial effects on lipid profiles that are the primary reason for taking high-dose niacin for cardiovascular health.¹³

It is a solution that solves the main side effect by eliminating the main effect.

The Liquid Mainline – A Direct Pipeline to the City

Finally, the investigation turned to liquid niacin, the focus of Alex’s engineering project.

In the city analogy, liquid niacin is a direct, high-pressure water main connected straight to the grid.

It bypasses the entire process of breaking down solid “pellets” (pills and capsules) in the digestive system.

The active ingredient is already dissolved and ready for immediate uptake.¹⁴

The theoretical advantages of this delivery system are significant.

Liquid supplements are often touted for their rapid absorption and potentially higher bioavailability—the proportion of a nutrient that actually enters the bloodstream and becomes available for use.¹⁴

For individuals who struggle with swallowing pills, or for those seeking precise, customizable dosing, liquids offer clear convenience.¹⁴

Some marketing materials for liquid supplements even use metaphors of swiftness, promising that nutrients “go to work fast” without waiting for pills to “kick in”.¹⁶

However, this is where a more sophisticated engineering analysis becomes crucial.

While the rapid absorption of a liquid vitamin might be a benefit for many nutrients, it is paradoxically its greatest liability in the context of high-dose niacin.

The very quality that consumers pay a premium for—speed—is the one that maximizes the most unpleasant and compliance-destroying side effect.

The research is unequivocal: the rate of niacin absorption is directly proportional to the intensity of the flush.¹⁰

A faster absorption rate leads to a more rapid saturation of the liver’s primary metabolic pathway, triggering a more powerful release of the prostaglandins that cause vasodilation and flushing.

Therefore, liquid niacin, as the fastest-absorbing formulation available, stands to produce the most potent and immediate flush of all.

This creates a fundamental tension: the advertised benefit is the direct cause of the primary drawback, a critical insight for any engineer considering this powerful tool.

Part III: Opening the Floodgates – Taming the Niacin Flush

The theoretical understanding was complete.

It was time for practical application.

Alex, now acting as the city’s chief engineer, decided to proceed with the liquid niacin protocol, fully aware of the potential for a system-wide alert.

The first dose was a memorable and humbling experience.

The Red Alert – A System Overload

Within twenty minutes of taking the first high-potency dose of liquid niacin, the alert began.

It started as a subtle warmth at the base of the neck, a strange prickling sensation like a thousand tiny needles.

Within moments, it blossomed into a wave of intense heat that surged upwards, engulfing the face, ears, and scalp.

A glance in the mirror revealed an alarming sight: the skin of the face, neck, and upper chest was a deep, blotchy red, as if from a severe sunburn.¹⁷

The feeling was intensely uncomfortable—a combination of burning, itching, and tingling that demanded attention.¹⁸

This was the niacin flush in its full, unmitigated glory.

While medical literature confirms the experience is physiologically harmless, it is profoundly disconcerting and is the single most common reason patients abandon niacin therapy, with some reports indicating that up to 20% of people prescribed niacin stop taking it because of the flush.¹⁷

The Science of the Surge – Why the Faucets All Open at Once

Having experienced the “what,” Alex was determined to understand the “why.” The flush is not an allergic reaction but a predictable pharmacological effect—a cascade of biochemical signals that can be traced from molecule to sensation.

Using the city analogy, the sudden, high-concentration influx of niacin from the “liquid mainline” acts as a system-wide alarm.

This alarm is detected by specialized sensor units embedded in the city’s infrastructure—immune cells in the skin known as dermal Langerhans cells.²⁰

When niacin molecules bind to a specific receptor on these cells, the G protein-coupled receptor 109A (GPR109A), it triggers an immediate response.²⁰

This binding action causes the Langerhans cells to release a flood of signaling chemicals, primarily arachidonic acid.

This acid is then rapidly converted by enzymes into powerful local hormones called prostaglandins, specifically prostaglandin D2 (PGD2​) and prostaglandin E2 (PGE2​).²⁰

These prostaglandins are the chemical messengers that travel through the local “waterways,” delivering an urgent command to the smallest distribution points: the

faucets of the capillaries near the skin’s surface.

The command is simple and direct: open wide, now.

This process, known as vasodilation, causes a massive, temporary surge of blood flow to the skin.¹³

The result is the visible redness and palpable heat of the flush.

The entire sequence, from the binding at the GPR109A receptor to the full-blown flush, is a beautiful and, when experienced, unnerving example of cellular communication.

The Engineer’s Control Panel – Mastering the Flow

Fear gives way to control when a phenomenon is understood.

The flush was no longer a mysterious and alarming reaction but a predictable outcome of a known mechanism.

This meant it could be managed.

Alex learned to operate the city’s “control panel,” implementing a series of evidence-based strategies to introduce the niacin without triggering a system-wide red alert.

1. Muting the Alarm Signal (Aspirin Pre-treatment): The most effective strategy is to prevent the prostaglandin signal from being sent in the first place. Prostaglandins are synthesized by cyclooxygenase (COX) enzymes. Aspirin is a COX inhibitor. By taking a standard 325 mg dose of aspirin approximately 30 minutes before the niacin, the engineer can effectively “mute” the alarm. The Langerhans cells still detect the niacin, but their ability to produce the prostaglandin messengers is blocked, dramatically reducing the intensity and likelihood of a flush.¹¹
2. Acclimating the System (Titration): The body develops a tolerance to the flushing effect over time.¹⁷ Therefore, starting with a very low dose and increasing it slowly over several weeks allows the system to acclimate. This gradual introduction prevents the shock of a sudden, high-concentration dose and allows the sensor cells to adapt.¹¹
3. Buffering the Surge (Take with Food): Administering the liquid niacin with a meal or a small, low-fat snack (an apple is often recommended) slows its absorption from the digestive tract.¹⁸ This acts as a buffer, preventing the instantaneous spike in blood concentration that is the primary trigger for the flush. It turns the “lightning strike” of a liquid dose on an empty stomach into something more manageable.²³
4. Avoiding Signal Amplifiers (Avoid Triggers): Hot beverages (like coffee or tea) and alcohol are also vasodilators; they send their own “open the faucets” signals to the capillaries. Consuming them around the time of a niacin dose can amplify the prostaglandin signal, resulting in a more intense flush. Avoiding these triggers is a simple and effective control measure.⁴

By implementing this multi-pronged protocol, Alex was able to tame the flush, transforming it from an intolerable side effect into a mild, manageable warmth.

The powerful tool of liquid niacin was now under engineering control.

Part IV: The Restoration Project – Niacin’s Role in a Thriving City

With the primary side effect managed, the final phase of the engineering project could begin: a clear-eyed evaluation of niacin’s true benefits and risks.

Alex’s journey started with a singular focus on fixing the “clogged pipes” of high cholesterol, but the investigation revealed a much more complex and nuanced story.

The solution was not a simple fix for one problem but a holistic strategy for managing the entire city.

Clearing the Pipes – The Evolving Cholesterol Story

The initial promise of niacin was its powerful effect on the city’s “water quality report”—the lipid panel.

The data is clear and long-standing: high-dose niacin is remarkably effective at improving cholesterol and triglyceride numbers.

It can lower the “sludge” of LDL cholesterol by 5-20%, slash the “floating barrels” of triglycerides by 20-50%, and, most impressively, boost the “maintenance crews” of HDL cholesterol by 15-35% or more—a feat unmatched by most other therapies.²

For decades, the logic seemed unassailable: better numbers should equal better outcomes.

However, more recent and rigorous engineering studies have complicated this narrative.

Large-scale clinical trials, such as AIM-HIGH and HPS2-THRIVE, examined what happened when niacin was added to the treatment regimen of patients already taking statins—the modern, highly effective “sludge-prevention system.” The results were surprising and sobering: adding niacin on top of a statin did not lead to a further reduction in major “pipe bursts” or “system failures” like heart attacks and strokes.²

In fact, one study noted a concerning trend toward an increase in all-cause mortality and other serious side effects in the niacin group.²⁶

This gave rise to the “niacin paradox”: why did a drug that so effectively improved lipid markers fail to improve clinical outcomes in the modern treatment era? A groundbreaking 2024 study may have found the answer.

Researchers discovered that when the body has an excess of niacin, it breaks it down into a metabolite known as 4PY.

This study found that high levels of 4PY in the blood were strongly associated with a higher risk of heart attack and stroke.

Furthermore, laboratory experiments showed that 4PY directly promotes inflammation in the blood vessels.²⁷

This suggests that while niacin is cleaning up the cholesterol sludge with one hand, its breakdown products may be actively inflaming the pipe walls with the other, potentially canceling out the benefits.

The engineering conclusion is that for a city already protected by a state-of-the-art statin system, adding the older niacin protocol may not only be redundant but potentially counterproductive.

Its primary role today is reserved for patients who cannot tolerate statins.²

Upgrading the Infrastructure – Beyond the Pipes

While niacin’s role as a frontline defense for the city’s pipes has been called into question, Alex’s investigation revealed that its benefits to other parts of the city’s infrastructure are undeniable and perhaps more relevant to the initial goal of restoring overall vitality.

• Reinforcing the City’s Outer Walls (Skin Health): Niacin, particularly in its topical form (niacinamide), is a well-documented agent for skin health. It helps protect skin cells from sun damage and has been shown in studies to reduce the incidence of nonmelanoma skin cancers in high-risk individuals.⁸ Its anti-inflammatory properties can help soothe conditions like acne and rosacea, effectively reinforcing the city’s protective outer barrier against environmental assaults.⁷
• Upgrading the Communication Grid (Brain Health): The initial feeling of “mental static” was directly tied to the city’s power grid. The brain is an energy-hungry organ that relies on a constant supply of ATP. By serving as the essential precursor to the energy-transfer coenzymes NAD and NADP, niacin is critical for proper brain function.⁶ Niacin deficiency is linked to severe cognitive symptoms, and some research suggests that maintaining optimal niacin levels may help protect brain cells from stress and injury, potentially improving cognitive function and offering a defense against age-related cognitive decline.⁷
• Stabilizing the Power Grid (Energy Levels): This is perhaps the most direct and subjectively noticeable benefit. By ensuring the body has the raw materials to efficiently convert food into cellular energy, niacin helps stabilize the entire power grid.⁹ The “brownouts” and “flickering lights” that characterized Alex’s fatigue were addressed at the most fundamental level—the metabolic process of energy creation itself.³⁰

The Building Code – A Guide to Safe and Responsible Use

Any powerful engineering tool comes with a strict set of operating procedures and safety warnings.

Niacin is no exception.

Ignoring the “building code” for its use can lead to significant problems.

This is not a supplement to be taken lightly or without professional guidance.

First and foremost, therapeutic doses of niacin (typically 500 mg and above) should only be used under the supervision of a qualified healthcare professional who can monitor for potential side effects.²

The most significant risk, particularly with older sustained-release formulations, is hepatotoxicity.

Regular monitoring of liver function through blood tests is a standard part of high-dose niacin therapy.³

There are also several contraindications.

Individuals with pre-existing liver disease, active peptic ulcers, or gout should use niacin with extreme caution, as it can exacerbate these conditions.¹

Furthermore, because high doses of niacin can affect glucose metabolism and increase blood sugar levels, individuals with diabetes must monitor their levels carefully and may require adjustments to their medications.⁶

It is also critical to be aware of the dangerous and unsupported off-label use of niacin to “flush” drugs out of the system to pass a drug test.

This practice is based on internet myths and has led to multiple documented cases of severe niacin toxicity, landing users in the hospital with life-threatening complications.³⁴

Table 2: High-Dose Niacin – Safety Profile & Key Interactions

Potential Risk	Who Is Most at Risk?	Key Symptoms to Watch For	Interacts With
Liver Damage (Hepatotoxicity)	Users of sustained-release (SR) forms; individuals with prior liver conditions; high alcohol consumption 3	Yellowing of skin/eyes (jaundice), dark urine, severe stomach pain, persistent nausea, loss of appetite 24	Alcohol, Statins (risk may increase), other hepatotoxic drugs 3
High Blood Sugar (Hyperglycemia)	Individuals with type 2 diabetes or metabolic syndrome 3	Increased thirst, frequent urination, fatigue, blurred vision, fruity-smelling breath 36	Diabetes medications (may require dose adjustment) 33
Gout Flare-up	Individuals with a history of gout 3	Sudden, severe pain, swelling, redness, and tenderness in a joint (often the big toe)	Allopurinol (may require dose adjustment) 3
Low Blood Pressure (Hypotension)	Individuals already on blood pressure medication; can be triggered by severe flushing 3	Dizziness, lightheadedness, fainting, blurred vision, rapid heartbeat 25	Blood pressure medications, alcohol 3
Increased Bleeding Risk	Individuals taking blood thinners 3	Unusual bruising, prolonged bleeding from cuts, nosebleeds, blood in urine or stool	Anticoagulants / Antiplatelet drugs (e.g., warfarin, aspirin) 3
Aggravation of Peptic Ulcers	Individuals with a history of stomach or intestinal ulcers 1	Burning stomach pain, feeling of fullness, bloating, heartburn, nausea 5	N/A

Conclusion: The City Reborn

The journey that began with a confusing lab report and a pervasive sense of malaise concluded with a profound shift in perspective.

Alex, having assumed the role of chief engineer, had transformed the city.

The initial goal was simple: fix the cholesterol numbers.

But the process revealed that a single metric could never capture the complexity of a living system.

Liquid niacin, the focus of the project, proved to be a powerful but nuanced tool.

Its reputation as a cholesterol-lowering agent, while technically accurate, is now overshadowed by a more complex clinical reality.

The true victory was not in finding a magic bullet for one problem, but in learning the language of the city’s interconnected systems.

The liquid niacin protocol, once tamed, delivered on a more fundamental promise: it helped restore the power grid.

The subjective experience of increased energy, mental clarity, and a lifting of the chronic fog was a direct result of supporting the body’s core metabolic machinery—the NAD and NADP pathways.

Ultimately, Alex realized the true solution wasn’t the niacin itself, but the knowledge and empowerment gained along the Way. It was the ability to read the schematics, to understand the interplay of hydraulics and electronics, and to take control of the engineering panel.

The city was reborn, not because of a single additive, but because its chief engineer was finally at the helm.

This journey underscores a universal truth of modern wellness: true vitality comes from a deep, evidence-based understanding of one’s own biology, undertaken as an active partnership with trusted healthcare professionals.

The most important first step is to start your own engineering report.

Works cited

1. Niacin for cholesterol: MedlinePlus Medical Encyclopedia, accessed on August 8, 2025, https://medlineplus.gov/ency/patientinstructions/000788.htm
2. Niacin to improve cholesterol numbers – Mayo Clinic, accessed on August 8, 2025, https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/niacin/art-20046208
3. Niacin – Mayo Clinic, accessed on August 8, 2025, https://www.mayoclinic.org/drugs-supplements-niacin/art-20364984
4. Niacin: MedlinePlus Medical Encyclopedia, accessed on August 8, 2025, https://medlineplus.gov/ency/article/002409.htm
5. Vitamin B3 – StatPearls – NCBI Bookshelf, accessed on August 8, 2025, https://www.ncbi.nlm.nih.gov/books/NBK526107/
6. 9 Benefits of Niacin (Vitamin B3) | Vinmec, accessed on August 8, 2025, https://www.vinmec.com/eng/blog/9-science-based-benefits-of-niacin-vitamin-b3-en
7. Niacin (Vitamin B3): Uses, Benefits, Sources & Side Effects, accessed on August 8, 2025, https://health.clevelandclinic.org/niacin-vitamin-b3
8. Niacin (Vitamin B3): Benefits, Dosage, and more – Healthline, accessed on August 8, 2025, https://www.healthline.com/nutrition/niacin-benefits
9. Niacin – Vitamin B3 – Harvard Nutrition Source, accessed on August 8, 2025, https://nutritionsource.hsph.harvard.edu/niacin-vitamin-b3/
10. (PDF) Overview of niacin formulations: Differences in …, accessed on August 8, 2025, https://www.researchgate.net/publication/10627949_Overview_of_niacin_formulations_Differences_in_pharmacokinetics_efficacy_and_safety
11. Niacin: The facts on flushing – the BC Drug and Poison Information Centre, accessed on August 8, 2025, http://www.dpic.org/article/professional/niacin-facts-flushing
12. Niacin and Heart Health – Fire Shaper, accessed on August 8, 2025, https://fireshaper.com/niacin-heart-health/
13. Niacin flush: Why does it occur? Is it dangerous? – Medical News Today, accessed on August 8, 2025, https://www.medicalnewstoday.com/articles/niacin-flush
14. Are Liquid Multivitamins More Effective Than Traditional Methods? – Texas Health Resources, accessed on August 8, 2025, https://www.texashealth.org/areyouawellbeing/Health-and-Well-Being/Are-Liquid-Multivitamins-More-Effective-Than-Traditional-Methods
15. Which Supplement Form is Best? – Seeking Health, accessed on August 8, 2025, https://www.seekinghealth.com/blogs/education/supplement-forms
16. Eyefortin Review: Legit or Overhyped? ~ What I Discovered After 212 Days (August 2025), accessed on August 8, 2025, https://www.fdl.wi.gov/wp-content/uploads/sites/12/ninja-forms/3/Eyefortin_2HMZGL.pdf
17. Is Niacin Flush Harmful? – Healthline, accessed on August 8, 2025, https://www.healthline.com/nutrition/niacin-flush
18. Niacin Flush: Causes, Symptoms, and Management – Health, accessed on August 8, 2025, https://www.health.com/niacin-flush-8670308
19. Niacin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing – WebMD, accessed on August 8, 2025, https://www.webmd.com/drugs/2/drug-3745-126/niacin-oral/niacin-supplement-oral/details
20. The mechanism and mitigation of niacin-induced flushing – PMC, accessed on August 8, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC2779993/
21. (PDF) The mechanism and mitigation of niacin-induced flushing – ResearchGate, accessed on August 8, 2025, https://www.researchgate.net/publication/26752350_The_mechanism_and_mitigation_of_niacin-induced_flushing
22. The mechanism and mitigation of niacin-induced flushing – PubMed, accessed on August 8, 2025, https://pubmed.ncbi.nlm.nih.gov/19691622/
23. What can prevent niacin-induced flushing? – Dr.Oracle, accessed on August 8, 2025, https://www.droracle.ai/articles/195517/what-can-prevent-the-niacin-flush
24. Niacin (oral route) – Side effects & dosage – Mayo Clinic, accessed on August 8, 2025, https://www.mayoclinic.org/drugs-supplements/niacin-oral-route/description/drg-20065086
25. Niacin for cholesterol Information | Mount Sinai – New York, accessed on August 8, 2025, https://www.mountsinai.org/health-library/special-topic/niacin-for-cholesterol
26. Niacin Too Dangerous for Routine Cholesterol Therapy – Northwestern Now, accessed on August 8, 2025, https://news.northwestern.edu/stories/2014/07/niacin-too-dangerous-for-routine-cholesterol-therapy-/
27. How Too Much Niacin Can Raise Your Risk of Heart Attack and Stroke, accessed on August 8, 2025, https://health.clevelandclinic.org/can-niacin-be-harmful-to-control-cholesterol
28. How excess niacin may promote cardiovascular disease | National Institutes of Health (NIH), accessed on August 8, 2025, https://www.nih.gov/news-events/nih-research-matters/how-excess-niacin-may-promote-cardiovascular-disease
29. Niacin (Vitamin B3): Benefits & Side Effects | Live Science, accessed on August 8, 2025, https://www.livescience.com/51825-niacin-benefits.html
30. Niacin: The Miracle Vitamin | Accent Physician Specialists, accessed on August 8, 2025, https://accentmd.com/blog/niacin-the-miracle-vitamin/
31. Niacin: Benefits, Uses & Top Supplements for Heart Health in 2025 – HealthyHey Nutrition, accessed on August 8, 2025, https://healthyhey.com/blogs/best-supplements-blog/your-whole-guide-to-niacins-uses-benefits-and-best-supplements-for-2025
32. Niacin – Content – Health Encyclopedia – University of Rochester Medical Center, accessed on August 8, 2025, https://www.urmc.rochester.edu/encyclopedia/content?contenttypeid=19&contentid=vitaminb-3
33. NIACIN AND NIACINAMIDE (VITAMIN B3): Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews – WebMD, accessed on August 8, 2025, http://www.webmd.com/vitamins/ai/ingredientmono-924/niacin-and-niacinamide-vitamin-b3
34. Beating the urine drug test – a case report on niacin toxicity – PMC, accessed on August 8, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC5906759/
35. NIACIN AND NIACINAMIDE (VITAMIN B3): Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews – WebMD, accessed on August 8, 2025, https://www.webmd.com/vitamins/ai/ingredientmono-924/niacin-and-niacinamide-vitamin-b3
36. Niacin (Niaspan, Slo Niacin, and others): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing – WebMD, accessed on August 8, 2025, https://www.webmd.com/drugs/2/drug-6142/nicotinic-acid-oral/details