Beyond the Pill: A Systems-Thinking Approach to Conquering Muscle Pain for Good

Introduction: The Revolving Door of Pain and a Moment of Crisis

The conventional approach to managing muscle pain often resembles a revolving door.

An individual experiences pain, seeks a solution—typically rest and an over-the-counter (OTC) medication—and finds temporary relief.

Weeks or months later, however, the same pain often returns, sometimes with greater intensity.

This cycle persists because it focuses on silencing the symptom rather than deciphering its message and addressing the root cause.

This methodology treats the body’s complex signaling network like a simple dashboard warning light that can be covered with a piece of tape, ignoring the underlying mechanical failure it indicates.

The limitations of this symptom-focused model are starkly illustrated by the case of a dedicated marathon runner who presented with persistent knee pain.

Following a standard playbook, her treatment plan involved rest and regular use of ibuprofen to manage the inflammation and pain, enabling her to continue training.

The NSAID performed its function, masking the pain signal effectively.

This effectiveness, however, proved to be a critical flaw.

The pain was a crucial warning of a severe underlying hip muscle imbalance that was causing her knee to track improperly during her stride.

By silencing this signal instead of decoding it, the underlying mechanical fault was allowed to persist and worsen.

The result was a catastrophic cartilage injury that ultimately required surgery and ended her competitive running career.

This outcome represents a profound failure of the conventional, symptom-centric approach and underscores the urgent need for a more integrated and analytical framework for understanding and managing muscle pain.

Part 1: The Epiphany – Why Treating Pain Like a Broken Car Part Fails

The search for a more effective framework leads to the unlikely field of systems engineering, a discipline used by organizations like NASA to design, manage, and maintain complex, integrated systems such as planetary rovers.¹

A systems engineer does not view a rover as a mere collection of independent parts.

Instead, they see an interconnected whole where the relationships between components are what create the system’s overall value and capability.¹

A wobble in a rover’s wheel is not treated as an isolated “wheel problem”; it is understood as a potential system-level issue that could originate in the suspension, the power distribution, the control software, or its interaction with the environment.³

To resolve the issue, one must understand how all parts function together within the entire system.⁴

This perspective provides a powerful new paradigm for human health: viewing the body as the ultimate complex system.

Within this framework, pain is not a broken part to be replaced or ignored.

It is a critical feedback signal—a warning light—generated by an integrated system to communicate its status.

The primary goal, therefore, should not be to simply turn off the light by taking a pill.

The goal should be to become the “systems engineer” of one’s own body: to analyze the entire system, understand what the signal is communicating about its overall health and performance, and address the root cause of the dysfunction.⁴

The fundamental error in conventional pain management is a failure of perspective.

It treats the body as a simple, linear machine where a single cause leads to a single effect.

In reality, the body is a complex, adaptive system with intricate feedback loops.

The case of the marathon runner exemplifies this.

The conventional approach saw “knee pain” and applied a “knee pain solution” (ibuprofen).

A systems-thinking approach would have asked, “Why is the knee subsystem sending a distress signal?” This question would have initiated an investigation of the entire kinetic chain—the foot, ankle, hip, and core—to identify the true source of the system imbalance before a catastrophic failure occurred.

This shift in focus from what is hurting to why it is hurting is the essence of this new paradigm.

Part 2: The Systems-Thinking Framework for Muscle Pain Mastery

Applying the principles of systems engineering to the human body yields a practical framework for managing muscle pain.

This framework is built on four essential pillars of system management: decoding the signal, selecting the right tool, repairing the system, and fortifying the system for long-term resilience.

Pillar I: Decode the Signal – Understanding Your Pain’s True Message

Before any intervention, the first step is to correctly interpret the message the pain signal is conveying.

Different types of muscle pain communicate distinct information about the system’s status and require different responses.

Signal Type 1: Acute Injury & Strain (The “Red Alert”)

This is the sharp, immediate pain resulting from a sprain, strain, or tear.

It is a clear, unambiguous signal from the body: “SYSTEM DAMAGE! PROTECT THIS AREA IMMEDIATELY!”.⁵

In response, the body initiates an inflammatory cascade, a necessary biological process involving swelling, redness, and pain, all of which are designed to protect the injured area and begin healing.⁷

The classic initial response protocol is the R.I.C.E.

method—Rest, Ice, Compression, and Elevation—designed to manage the overwhelming initial phase of this signal.⁹

However, modern sports medicine has evolved this understanding, recognizing that excessive rest and ice may actually delay healing by overly suppressing the necessary inflammatory response.¹²

This has led to the development of newer protocols, such as PEACE & LOVE (Protect, Elevate, Avoid Anti-inflammatories, Compress, Educate & Load, Optimism, Vascularisation, Exercise), which reflect a more nuanced approach of managing, rather than eliminating, the body’s natural healing processes.

Signal Type 2: Delayed Onset Muscle Soreness (DOMS) (The “System Upgrade in Progress” Signal)

This is the dull, aching pain that typically appears 24 to 48 hours after a new or particularly intense workout.

This signal does not indicate damage in the same way an acute injury does.

Instead, it is a sign that the muscle has undergone microscopic trauma and is now in the process of rebuilding itself to be stronger and more resilient—an essential part of adaptation and growth.¹³

The inflammation associated with DOMS is productive, serving to deliver nutrients and trigger the biological signals required for muscle repair and hypertrophy.¹³

Treating this productive signal with aggressive anti-inflammatory measures is akin to halting a factory assembly line during a planned equipment upgrade; it interferes directly with the desired outcome of getting stronger.

Signal Type 3: Chronic Pain (The “Persistent System Error” Signal)

Chronic pain is defined as pain that persists for more than three months.¹⁵

In this state, the original injury may have healed, but the pain signal itself has become the problem.

The nervous system has become sensitized and is stuck in a maladaptive feedback loop, continuously broadcasting a “Red Alert” even in the absence of new tissue damage.¹⁶

This persistent system error can be driven by unaddressed mechanical faults (like the runner’s hip imbalance), ongoing systemic inflammation from diet or lifestyle, or a phenomenon known as central sensitization, where the brain and nerves become hyper-reactive to stimuli.¹⁶

Pillar II: Select the Right Tool – Strategic Use of OTC Medication

Once the pain signal has been decoded, the next step is to select the appropriate tool from the systems engineer’s toolkit.

OTC medications are not cures; they are specialized instruments to be used strategically, with a clear understanding of their function, best application, and systemic cost.

Tool #1: The Anti-Inflammatory Toolkit (NSAIDs – Ibuprofen, Naproxen, Aspirin)

Nonsteroidal anti-inflammatory drugs (NSAIDs) function by inhibiting cyclooxygenase (COX) enzymes, which are responsible for producing inflammatory chemicals called prostaglandins.¹⁹

There are two key forms of this enzyme:

• COX-1: This is a “housekeeping” enzyme that is always present. It plays a protective role in maintaining the stomach lining, supporting kidney function, and enabling platelet aggregation for blood clotting.²⁰ Blocking COX-1 is the primary cause of the most common NSAID side effects.
• COX-2: This is an “emergency” enzyme that is produced in response to injury and inflammation. Its activity leads to the sensations of pain and swelling. Blocking COX-2 is the main therapeutic goal of NSAIDs.²⁰

Best Use Cases: NSAIDs are most effective for managing the “Red Alert” signal of an acute, inflammation-driven injury, particularly within the first 24 to 72 hours.

They help control severe swelling and pain, allowing for basic function.⁵

Naproxen (e.g., Aleve) offers a longer-lasting effect of 8 to 12 hours, making it convenient for sustained relief, whereas ibuprofen (e.g., Advil, Motrin) has a shorter 4- to 6-hour duration of action.¹⁹

Systemic Risks & Trade-offs: Using this powerful tool comes at a cost to the overall system.

• Gastrointestinal Risk: By inhibiting the protective COX-1 enzyme, NSAIDs increase the risk of stomach upset, heartburn, and ulcers.²⁰
• Cardiovascular Risk: Long-term use of NSAIDs is associated with an increased risk of heart attack and stroke, especially in individuals with pre-existing heart disease.²⁰
• Renal (Kidney) Risk: NSAIDs can impair kidney function by reducing blood flow, a significant concern for those with kidney disease, dehydration, or who are older adults.²⁰
• The DOMS Conflict: As noted, using NSAIDs for the “System Upgrade” signal of DOMS can blunt the inflammatory response necessary for muscle adaptation and growth. Studies suggest high-dose ibuprofen may inhibit muscle gains compared to lower-impact alternatives.¹³

Tool #2: The Central Pain-Control Toolkit (Acetaminophen)

It is critical to understand that acetaminophen (e.g., Tylenol) is not an NSAID.¹⁹

Its mechanism is not primarily anti-inflammatory.

Instead, it is thought to work centrally within the brain and spinal cord, elevating the body’s overall pain threshold so that a greater amount of stimulus is required to be felt as pain.¹⁹

Its complex mechanism involves metabolites like AM404 that influence various pain pathways, including the TRPV1 and cannabinoid systems.²⁸

It has very weak anti-inflammatory effects in the rest of the body.²⁸

Best Use Cases: Acetaminophen is an excellent choice for non-inflammatory pain, such as some forms of osteoarthritis or tension headaches.

It is the preferred tool when the “Red Alert” of an acute injury has subsided but pain lingers without significant swelling.

It is also the safer option for individuals with stomach issues, kidney disease, or cardiovascular risks who cannot tolerate the systemic effects of NSAIDs.¹⁹

Systemic Risks & Trade-offs: The primary and most serious risk associated with acetaminophen is severe liver damage (hepatotoxicity) from overdose.¹⁹

This occurs when the body’s supply of a detoxifying agent called glutathione is depleted, leading to the buildup of a toxic metabolite, NAPQI.²⁸

It is imperative to adhere to the maximum daily dose (typically 3,000 to 4,000 mg for adults) and to be vigilant about checking the labels of other medications (like cold and flu remedies) for hidden acetaminophen.²⁵

Tool #3: The Localized Intervention Toolkit (Topical Analgesics)

Topical treatments offer a significant advantage by bypassing the systemic circulation and delivering medication directly to the target tissue.³⁰

This minimizes the risk of systemic side effects.

• Topical NSAIDs (e.g., Diclofenac/Voltaren): These work by inhibiting COX enzymes locally in the muscles and joints where they are applied, reducing inflammation at the source.³²
• Counterirritants (e.g., Menthol, Camphor): Found in products like Icy Hot or BenGay, these ingredients create a cooling or warming sensation that stimulates nerve endings. This acts as a distraction, effectively closing the “gate” to the underlying pain signal traveling to the brain.³⁴
• Anesthetics (e.g., Lidocaine): These products temporarily block local nerve signals, producing a numbing effect in the application area.³⁶
• Capsaicin: Derived from chili peppers, this unique ingredient works by first stimulating and then desensitizing the TRPV1 pain and heat receptors in the skin with repeated use.³³

Best Use Cases: Topicals are excellent for pinpoint pain in joints and muscles close to the skin’s surface, such as the knees, elbows, hands, and ankles.³⁰

They are a fantastic first-line option for individuals with systemic health concerns (gastrointestinal, cardiovascular, or kidney disease) who need targeted relief without the risks of oral medications.³²

Systemic Risks & Trade-offs: The primary risk is localized skin irritation, redness, or a burning sensation at the application site.³¹

Their main limitation is that they are not effective for deep muscle pain or for widespread pain that affects multiple joints simultaneously.³²

The selection of an OTC medication is a classic engineering trade-off analysis.

There is no single “best” option, only an “optimal” choice for a specific problem under specific constraints.

NSAIDs offer high performance against inflammation but at a high systemic cost.

Acetaminophen offers a better safety profile for many systems but provides no anti-inflammatory benefit.

Topicals provide targeted performance with the lowest systemic cost but for a very limited set of applications.

Drug Class	Example Brands	Primary Mechanism (Simplified)	Best For (Pain Signal Type)	Key Systemic Risks (GI, Liver, Cardio, Kidney)	Dosing Interval
Ibuprofen	Advil, Motrin	Blocks COX-1 & COX-2 enzymes to reduce inflammation and pain system-wide.20	Acute Injury (“Red Alert”) with inflammation and pain.22	High GI, moderate Cardio/Kidney risk.20	4-6 hours 24
Naproxen	Aleve	Blocks COX-1 & COX-2 enzymes to reduce inflammation and pain system-wide.20	Acute Injury (“Red Alert”) requiring longer-lasting relief.22	High GI, moderate Cardio/Kidney risk.20	8-12 hours 19
Aspirin	Bayer, Anacin	Irreversibly blocks COX-1 & COX-2; also has anti-platelet effects.21	Acute Injury (“Red Alert”); also used for cardiovascular prevention.19	High GI risk; bleeding risk; Reye’s syndrome in children.25	4-6 hours
Acetaminophen	Tylenol, Panadol	Works in the central nervous system to block pain signals; not an anti-inflammatory.19	Non-inflammatory pain; pain without swelling; for those with NSAID risks.27	High Liver risk with overdose; low GI/Cardio/Kidney risk.19	4-6 hours 24
Topical Diclofenac	Voltaren Gel	Blocks COX enzymes locally in the tissue where applied.32	Localized joint/muscle pain (e.g., knee, elbow arthritis).32	Low systemic risk; main risk is skin irritation.31	Varies by product
Topical Counterirritants	Icy Hot, BenGay	Creates a distracting sensation (hot/cold) on the skin to mask pain.34	General muscle soreness; mild aches and pains.35	Low systemic risk; main risk is skin irritation/burns.41	Varies by product
Topical Lidocaine	Aspercreme with Lidocaine	Temporarily blocks local nerve signals to numb the area.36	Localized nerve-related pain or intense surface pain.36	Low systemic risk; main risk is skin irritation.38	Varies by product
Topical Capsaicin	Zostrix	Stimulates and then desensitizes nerve endings.33	Chronic nerve pain, arthritis pain (requires consistent use).33	Low systemic risk; causes initial burning sensation.35	Varies by product

Pillar III: Repair the System – Active, Non-Pharmacological Solutions

Once an overwhelming “Red Alert” signal is managed, the true work of the systems engineer begins: diagnosing and repairing the underlying fault.

Medication does not fix faulty mechanics; targeted movement and therapeutic interventions do.

Temperature Modulation: Calibrating the Environment

The strategic application of heat and cold can help create an optimal environment for healing.

• Cold Therapy (Ice): Best suited for acute injuries within the first 48 hours. Cold constricts blood vessels, which helps reduce swelling, limit internal bleeding, and numb sharp pain.⁸ It is a tool for managing an out-of-control initial inflammatory response.
• Heat Therapy: Best for chronic stiffness, lingering muscle soreness (like DOMS), and warming up before activity. Heat increases blood flow to the area, which helps relax tight muscles and improve tissue flexibility.⁸ Applying heat to a fresh, swollen injury is counterproductive, as it can dilate blood vessels and worsen the swelling.⁴²

Movement as Medicine: The Active Repair Crew

A robust recovery plan often requires the expertise of movement professionals who can assess the system at different levels.

• The Physical Therapist (The Component Specialist): A physical therapist is an expert in diagnosing and treating specific, damaged tissues.¹⁶ They employ techniques like manual therapy, joint mobilization, and targeted restorative exercises to promote healing in a damaged component, such as a strained hamstring or a sprained ligament.¹⁵ Their focus answers the question: “How do we heal this specific part?”
• The Kinesiologist (The Integration Specialist): A kinesiologist analyzes the entire system’s movement patterns (biomechanics) to identify the root cause of the component’s failure.⁴⁷ Using tools like functional movement screens and gait analysis, they identify the subtle imbalances, weaknesses, and postural inefficiencies that lead to repetitive stress and injury.⁴⁸ Their focus answers the question: “Why did this part fail, and how do we prevent it and other parts from failing again?” This top-down, integrative view is crucial for long-term resilience. The marathon runner from the introduction required both: a physical therapist to help heal her damaged knee cartilage and a kinesiologist to identify and correct the hip imbalance that caused the problem in the first place.

The Power of Stretching

Stretching is a fundamental tool for system maintenance, improving flexibility, increasing muscle blood flow, and enhancing joint range of motion.⁵⁰

However, not all stretching is the same, and the right technique depends on the goal.

• Dynamic Stretching: This involves active, controlled movements through a full range of motion (e.g., leg swings, torso twists). It is best used as part of a warm-up to increase muscle temperature and prepare the body for activity.⁵³
• Static Stretching: This involves holding a stretch for a sustained period (typically 30-60 seconds). It is most effective during a cool-down after exercise to improve long-term flexibility and lengthen muscle tissue.⁵¹
• Caution: It is important to avoid aggressive stretching of a severely sore or acutely injured muscle, as this can cause further micro-tearing and damage.⁵³

Pillar IV: Fortify the System – Proactive Lifestyle Integration

A well-engineered system is not just repaired; it is fortified to be more resilient.

This final pillar focuses on the long-term, proactive strategies that optimize the body’s internal environment, making it less susceptible to pain signals.

Input #1: Anti-Inflammatory Nutrition

Chronic, low-grade systemic inflammation is a major driver of persistent pain.

Diet is one of the most powerful levers for controlling this biochemical environment.¹⁸

A Mediterranean-style diet, which emphasizes fruits, vegetables, whole grains, nuts, and healthy fats like olive oil while limiting processed foods, has been shown to have significant health benefits.¹⁸

Certain nutrients and supplements have also demonstrated anti-inflammatory and pain-reducing properties:

• Omega-3 Fatty Acids: Found in fish oil, these can help manage inflammation.¹³
• Curcumin: The active compound in turmeric, it has well-documented anti-inflammatory effects.¹⁴
• Vitamin D and Magnesium: Deficiencies in these micronutrients have been linked to chronic pain conditions like fibromyalgia, and supplementation may reduce symptoms.¹⁸

Input #2: The Mind-Body Connection

The “system” is not purely biomechanical; it is also biochemical and neurological.

Pain is not just a physical sensation but an experience that is profoundly interpreted and modulated by the brain.

Factors like stress, anxiety, and negative thought patterns can amplify pain signals, while relaxation and mindfulness can dampen them.⁵⁵

• Stress Management and Relaxation Therapy: Techniques like deep breathing and progressive muscle relaxation can help calm an overactive nervous system, reducing muscle tension and interrupting the stress-pain cycle.⁵⁷
• Mindfulness and Meditation: These practices involve learning to observe physical sensations (like pain) without judgment. This can help decouple the raw physical sensation from the emotional suffering that often accompanies it, thereby reducing the overall burden of pain.⁵⁵
• Cognitive Behavioral Therapy (CBT): This is a well-established therapeutic approach that helps individuals identify, challenge, and reframe the negative thought patterns and behaviors that can perpetuate and worsen the experience of chronic pain.⁵⁵

Conclusion: Becoming the Engineer of Your Own System

The journey from being a passive recipient of pain to an active manager of a complex system represents a fundamental paradigm shift.

The goal is no longer to simply silence a pain signal, but to understand its message, strategically select the right tools for the job, repair the underlying cause, and fortify the entire system against future failure.

This framework is demonstrated by the case of an office worker who suffered from chronic low back pain and had become reliant on daily naproxen.

By applying the Systems-Thinking approach, his pain was first decoded as a “Persistent System Error.” To manage acute flare-ups while minimizing systemic risk, he switched from oral NSAIDs to a topical diclofenac gel.

A kinesiological assessment then identified the root cause of the system error: weak gluteal muscles and poor desk ergonomics that placed continuous strain on his lower back.

A targeted strengthening program, combined with dietary changes to lower his baseline inflammation and mindfulness practices to manage work-related stress, allowed him to break the cycle of pain.

He successfully became the engineer of his own system, moving from dependence on medication to a state of empowered self-management.

Ultimately, the most powerful tool for conquering muscle pain is not found in a pill bottle.

It is the knowledge and perspective to understand one’s own body as a sophisticated, integrated system.

By learning to decode its signals, address root causes, and build a more resilient and functional life, anyone can move beyond the revolving door of pain.

Works cited

1. SEH 2.0 Fundamentals of Systems Engineering – NASA, accessed on August 12, 2025, https://www.nasa.gov/reference/2-0-fundamentals-of-systems-engineering/
2. 5.2 The aims and principles of system engineering – The Open University, accessed on August 12, 2025, https://www.open.edu/openlearn/science-maths-technology/systems-engineering-challenging-complexity/content-section-5.2
3. What is Systems Engineering? – Jama Software, accessed on August 12, 2025, https://www.jamasoftware.com/requirements-management-guide/systems-engineering/what-is-systems-engineering/
4. Introduction to Systems Engineering – SEBoK, accessed on August 12, 2025, https://sebokwiki.org/wiki/Introduction_to_Systems_Engineering
5. Muscle strain treatment: MedlinePlus Medical Encyclopedia, accessed on August 12, 2025, https://medlineplus.gov/ency/article/002116.htm
6. RICE Treatment – St. Charles Health System, accessed on August 12, 2025, https://stcharleshealthcare.org/news/rice-treatment
7. Ibuprofen Mechanism – News-Medical.net, accessed on August 12, 2025, https://www.news-medical.net/health/Ibuprofen-Mechanism.aspx
8. Ice Packs vs. Warm Compresses For Pain | Johns Hopkins Medicine, accessed on August 12, 2025, https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/ice-packs-vs-warm-compresses-for-pain
9. my.clevelandclinic.org, accessed on August 12, 2025, https://my.clevelandclinic.org/health/treatments/rice-method#:~:text=The%20RICE%20method%20is%20a,bleeding%20in%20your%20soft%20tissues.
10. RICE Method: Rest, Ice, Compression, & Elevation – Cleveland Clinic, accessed on August 12, 2025, https://my.clevelandclinic.org/health/treatments/rice-method
11. RICE (rest, ice, compression, and elevation) – UK HealthCare, accessed on August 12, 2025, https://ukhealthcare.uky.edu/orthopaedic-surgery-sports-medicine/treatment/rice
12. Is There a Better Way to Use RICE for Your Injury? > News > Yale Medicine, accessed on August 12, 2025, https://www.yalemedicine.org/news/rice-protocol-for-injuries
13. Discover Best Pain Reliever for Sore Muscles After Workout – Unlocking Insights – Explore Our Articles – InsideTracker, accessed on August 12, 2025, https://www.insidetracker.com/a/articles/what-helps-sore-muscles-after-workout
14. Should You Take Pain Relievers for Exercise-Induced Aches?, accessed on August 12, 2025, https://www.outsideonline.com/health/training-performance/should-you-take-pain-relievers-for-exercise-induced-aches
15. How Physical Therapy Helps with Chronic Pain Management, accessed on August 12, 2025, https://www.startptnow.com/blog/how-physical-therapy-helps-with-chronic-pain-management
16. Pain Relief Through Physical Therapy | University of Utah Health, accessed on August 12, 2025, https://healthcare.utah.edu/healthfeed/2025/01/pain-relief-through-physical-therapy
17. Chronic Pain Management: The Benefits of Physical Therapy, accessed on August 12, 2025, https://sportsandortho.net/chronic-pain-management-the-benefits-of-physical-therapy/
18. Non-Drug Approaches to Chronic Pain – Whole Health Library – VA.gov, accessed on August 12, 2025, https://www.va.gov/WHOLEHEALTHLIBRARY/tools/non-drug-approaches-to-chronic-pain.asp
19. NSAIDs vs. Acetaminophen: Which Over-the-Counter Medicine …, accessed on August 12, 2025, https://www.yalemedicine.org/news/acetaminophen-nsaids-over-the-counter-pain-relievers
20. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) – StatPearls – NCBI …, accessed on August 12, 2025, https://www.ncbi.nlm.nih.gov/books/NBK547742/
21. Nonsteroidal anti-inflammatory drug – Wikipedia, accessed on August 12, 2025, https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug
22. What Kind of Pain Reliever Is Best for Me? – Duke Health, accessed on August 12, 2025, https://www.dukehealth.org/blog/what-kind-of-pain-reliever-best-me
23. NSAIDs (Nonsteroidal Anti-Inflammatory Drugs): Uses – Cleveland Clinic, accessed on August 12, 2025, https://my.clevelandclinic.org/health/treatments/11086-non-steroidal-anti-inflammatory-medicines-nsaids
24. Muscle Relaxers: Best Over-The-Counter and Rx Options – Sesame, accessed on August 12, 2025, https://sesamecare.com/blog/otc-prescription-muscle-relaxers
25. Over-the-counter pain relievers: MedlinePlus Medical Encyclopedia, accessed on August 12, 2025, https://medlineplus.gov/ency/article/002123.htm
26. Over the Counter Pain Medications: What to Consider | Brown University Health, accessed on August 12, 2025, https://www.brownhealth.org/be-well/over-counter-pain-medications-what-consider
27. Acetaminophen Explained: Uses, Dosage & Safety | TYLENOL®, accessed on August 12, 2025, https://www.tylenol.com/safety-dosing/what-is-acetaminophen
28. Analgesic Effect of Acetaminophen: A Review of Known and Novel …, accessed on August 12, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC7734311/
29. Mechanism of Action of Acetaminophen: Is There a Cyclooxygenase 3? – Oxford Academic, accessed on August 12, 2025, https://academic.oup.com/cid/article/31/Supplement_5/S202/334078
30. Why Topical Pain Cream is better than Swallowing Pills for Pain Relief, accessed on August 12, 2025, https://greatearthpharmacy.com/2014/07/07/topical-pain-cream-better-swallowing-pills-pain-relief/
31. Why Use Topical Analgesic Creams? | TYLENOL®, accessed on August 12, 2025, https://www.tylenol.com/adult-relief/muscles/benefits-of-topicals
32. What Are Topical Anti-Inflammatory Creams?, accessed on August 12, 2025, https://health.clevelandclinic.org/anti-inflammatory-cream
33. Topical Analgesics – SciELO, accessed on August 12, 2025, https://www.scielo.br/j/rba/a/jFRMy4hJs8VfPDCC3fTrgdQ/?format=pdf&lang=en
34. Do topical pain relievers work? – Uniprix, accessed on August 12, 2025, https://www.uniprix.com/en/tips/1/health/do-topical-pain-relievers-work
35. How Do Topical Analgesics Work? – Uses, Side Effects, Drug Names – RxList, accessed on August 12, 2025, https://www.rxlist.com/how_do_topical_analgesics_work/drug-class.htm
36. Transdermal and Topical Drug Administration in the Treatment of Pain – MDPI, accessed on August 12, 2025, https://www.mdpi.com/1420-3049/23/3/681
37. Topical vs Oral Anti-Inflammatory Options – Arthritis and Injury Care, accessed on August 12, 2025, https://arthritisandinjurycare.com/topical-vs-oral-anti-inflammatory-options/
38. The pharmacology of topical analgesics – PubMed, accessed on August 12, 2025, https://pubmed.ncbi.nlm.nih.gov/24547599/
39. Over-the-Counter Pain Relievers: Which One Should You Take? | ColumbiaDoctors, accessed on August 12, 2025, https://www.columbiadoctors.org/news/over-counter-pain-relievers-which-one-should-you-take
40. Acetaminophen for Arthritis Pain Relief: Osteoarthritis & Inflammatory Types, accessed on August 12, 2025, https://arthritis.ca/treatment/medication/medication-reference-guide/medications/acetaminophen
41. Topical Analgesics Provide Pain Relief – Pharmacy Times, accessed on August 12, 2025, https://www.pharmacytimes.com/view/topical-analgesics-provide-pain-relief
42. When to treat pain with ice vs heat – Piedmont Healthcare, accessed on August 12, 2025, https://www.piedmont.org/living-real-change/when-to-treat-pain-with-ice-vs-heat
43. Ice vs Heat: What’s Better for Pain Relief? – Orthopedic Institute, accessed on August 12, 2025, https://orthopedicinstitutesf.com/ice-vs-heat-whats-better-for-pain-relief/
44. Treating Pain with Heat and Cold – Healthline, accessed on August 12, 2025, https://www.healthline.com/health/chronic-pain/treating-pain-with-heat-and-cold
45. Physical Therapy Guide to Pain | Choose PT, accessed on August 12, 2025, https://www.choosept.com/guide/physical-therapy-guide-pain
46. The Role Of Physical Therapy With Traditional Pain Management Strategies | Los Angeles, accessed on August 12, 2025, https://www.advancedpainmedical.com/physical-therapy-with-traditional-pain-management-strategies/
47. Effective Healing: Common Injuries Treated with Kinesiology …, accessed on August 12, 2025, https://elevationrehab.ca/common-injuries-treated-with-kinesiology/
48. Transform Your Pain With Science-Backed Kinesiology – Kinlab, accessed on August 12, 2025, https://kinlab.ca/transform-your-pain-with-science-backed-kinesiology/
49. The Role of Kinesiology in Injury Prevention and Rehabilitation – Muscle Release Massage Therapy, accessed on August 12, 2025, https://www.musclereleasemassage.com/blog/the-role-of-kinesiology-in-injury-prevention-and-rehabilitation
50. The simple act of stretching – Center for Healthy Aging – Vice President For Research, accessed on August 12, 2025, https://www.research.colostate.edu/healthyagingcenter/2021/06/23/the-simple-act-of-stretching/
51. Stretching: Focus on flexibility – Mayo Clinic, accessed on August 12, 2025, https://www.mayoclinic.org/healthy-lifestyle/fitness/in-depth/stretching/art-20047931
52. Simple Stretches to Relieve Chronic Pain – Mather Hospital, accessed on August 12, 2025, https://www.matherhospital.org/weight-loss-matters/simple-stretches-to-relieve-chronic-pain/
53. The Three Biggest Myths About Stretching – Adidas, accessed on August 12, 2025, https://www.adidas.com/us/blog/533438-the-three-biggest-myths-about-stretching
54. What to Know About Delayed Onset Muscle Soreness (DOMS) – Healthline, accessed on August 12, 2025, https://www.healthline.com/health/doms
55. An update on non-pharmacological interventions for pain relief – PMC – PubMed Central, accessed on August 12, 2025, https://pmc.ncbi.nlm.nih.gov/articles/PMC11866493/
56. Topic D: Non-pharmacologic pain management – OUOUD – Canadian Association of Schools of Nursing, accessed on August 12, 2025, https://ououd.casn.ca/modules/module-7/topic-7d.html
57. Non-Drug Pain Management – MedlinePlus, accessed on August 12, 2025, https://medlineplus.gov/nondrugpainmanagement.html
58. 4 Ways To Manage Chronic Pain Without Medication | Henry Ford Health, accessed on August 12, 2025, https://www.henryford.com/blog/2017/07/4-ways-manage-chronic-pain-without-medication